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| Zhao,Yanyin; Liu,Bingyou; Wang,Yi; Xiao,Baoguo. |
| This study aimed to investigate the therapeutic effect of fasudil on treating experimental autoimmune neuritis (EAN). Twenty-four EAN mice were randomly assigned to fasudil treatment (Fasudil group) or saline treatment (EAN model group) for 28 days. Clinical symptom score was evaluated every other day; inflammatory cell infiltration, demyelination, anti-myelin basic protein (MBP), inflammatory cytokines, inducible nitric oxide synthase (iNOS), and arginase-1 were detected in sciatic nerves at day 28. Th1, Th2, Th17, and Tregs proportions in splenocytes were detected at day 28. Clinical symptom score was found to be attenuated in the Fasudil group compared to the EAN model group from day 12 to day 28. Sciatic nerve inflammatory cell counts by HE staining... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Fasudil; Experimental autoimmune neuritis; Th1; Th17; Tregs; M2 macrophages polarization. |
| Ano: 2020 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2020000100607 |
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| Yang,Xia; Qian,Feng; He,Hai-Yang; Liu,Kai-Jun; Lan,Yuan-Zhi; Ni,Bing; Tian,Yi; Fu,Xiao-Lan; Zhang,Ji; Shen,Zi-Gang; Li,Jian; Yin,Yi; Li,Jin-Tao; Wu,Yu-Zhang. |
| Thymosin alpha 1 (Tα1) has been shown to have beneficial effects on numerous immune system parameters, but little is known about the effects of Tα1 on patients with gastric carcinoma. The objective of this study was to determine the effect of Tα1 on subpopulations of Th1, Th2, Th17, and regulatory T cells (Tregs) in vitro, and to evaluate its efficacy as an immunoregulatory factor in patients with gastric carcinoma. We compared the effect of Tα1 on the frequency of CD4+ and CD8+ T cells, especially the CD4+CD25+Foxp3+ Tregs in peripheral blood mononuclear cells (PBMCs) from gastric carcinoma patients (N = 35) and healthy donors (N = 22). We also analyzed the changes in the proliferation of PBMCs in response to treatment with Tα1, and examined the... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Tα1; Gastric carcinoma; Tregs; Th1; Th2; Th17. |
| Ano: 2012 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2012000100005 |
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| Ávalos,Ana María; Apablaza,Felipe A; Quiroz,Mariana; Toledo,Viviana; Peña,Juan Pedro; Michea,Luis; Irarrazabal,Carlos E; Carrión,Flavio A; Figueroa,Fernando E. |
| Th17 cells, a recently described subtype of CD4+ effector lymphocytes, have been linked to cell-mediated autoimmune and inflammatory diseases as well as to cardiovascular diseases. However, the participation of IL-17A in myocardial ischemic injury has not been clearly defined. We therefore conducted the present study to evaluate IL-17A and Th17-related cytokine levels in a rat model of myocardial infarction (MI). MI was induced in male Sprague Dawley rats by coronary artery ligation. Controls were sham-operated (Sh) or non-operated (C). Blood and samples from the left ventricle (LV) were collected at weeks 1 and 4 post-MI. At week 1, MI animals exhibited increased IL-6, IL-23 and TGF-β mRNA levels with no apparent change in IL-17 mRNA or protein... |
| Tipo: Journal article |
Palavras-chave: Interleukin-17; Th17; Myocardial infarction; Cardiovascular disease. |
| Ano: 2012 |
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602012000200012 |
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| Luo,Jie; Zhang,Mingxu; Yan,Baosong; Zhang,Kejun; Chen,Ming; Deng,Shaoli. |
| Abstract Objective: Maintaining a right balance between Th17 and Treg might be critical to the immunopathogenesis of active tuberculosis (TB). This study aimed to assess whether the Th17/Treg balance is altered in active TB patients. Methods: 250 study subjects (90 active TB patients, 80 latent TB subjects, and 80 healthy controls) were recruited for the study. The expression of Th17 and Treg in peripheral blood mononuclear cells (PBMCs) in the 250 subjects was investigated by flow cytometry. Plasma levels of cytokines IL-17 and IL-10, which are related to Th17 and Treg, respectively, were determined by ELISA. Results: The percentages of Th17 and Treg in PBMCs from active TB patients were significantly higher than those from latent TB or control groups... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Active tuberculosis; Th17; Treg; IL-17; IL-10. |
| Ano: 2017 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1413-86702017000200155 |
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